Nature Cancer 2021 · Multifunctional oncolytic nanoparticles · IL-12 saRNA · Yingzhong Li (MIT · first author · pre-SunVax)

"Therapies that synergistically stimulate immunogenic cancer cell death (ICD), inflammation, and immune priming are of great interest for cancer immunotherapy." Self-replicating RNAs delivered in lipid nanoparticles · cell-death promotion + danger signal stimulation + IL-12 expr…

Type

paper

Domain

oncology

Grade

conference

License

LIGHT_HOPE_proprietary

Provenance

m622_command_round_13_q15_activation_2026-05-17

evidence_grade

A

category

founder_academic_origin_publication

status

verified

instance_tag

sunvax-antibody-2025

clinical_claim_softening

"preclinical oncolytic nanoparticle paper · self-replicating RNA + IL-12 · NOT clinical data · not intended to guide individual patient treatment choices"

journal

Nature Cancer

year

2021

authors

Yingzhong Li,Ron Weiss,{"notable_coauthors":["Zhijun Su","Weiyu Zhao","Xinfu Zhang","Noor Momin","Chengxiang Zhang","K Dane Wittrup (MIT)","Yizhou Dong (Ohio State)","Darrell J Irvine (MIT · Ragon · HHMI)"]}

abstract_snippet

"Therapies that synergistically stimulate immunogenic cancer cell death (ICD), inflammation, and immune priming are of great interest for cancer immunotherapy." Self-replicating RNAs delivered in lipid nanoparticles · cell-death promotion + danger signal stimulation + IL-12 ex

pmid

34447945

doi

10.1038/s43018-020-0095-6

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