Comm Biology 2025 · CATP cascade amplification of therapeutic payloads · Yingzhong Li (SunVax · first/corresponding)

"Achieving sufficient therapeutic payload delivery remains a significant challenge in gene therapy, particularly for cancer immunotherapy, where payload thresholds are critical for efficacy. To address this, we developed a Cascade Amplification of Therapeutic Payloads (CATP) sys…

Type

paper

Domain

oncology

Grade

conference

License

LIGHT_HOPE_proprietary

Provenance

m622_command_round_13_q15_activation_2026-05-17

evidence_grade

A

category

sunvax_founder_publication

status

verified

instance_tag

sunvax-antibody-2025

clinical_claim_softening

"preclinical CATP system paper · cancer immunotherapy mechanism · NOT validated clinical outcome data · not intended to guide individual patient treatment choices"

journal

Communications Biology

year

2025

authors

Yingzhong Li,Libin Zhang,{"other_sunvax_authors":["Jiayu Wu","Na Li","Maoqing Wu"]},{"umich_authors":["Zongqi Wang (University of Michigan Biomedical Engineering)","Jiahe Li (University of Michigan)"]}

abstract_snippet

"Achieving sufficient therapeutic payload delivery remains a significant challenge in gene therapy, particularly for cancer immunotherapy, where payload thresholds are critical for efficacy. To address this, we developed a Cascade Amplification of Therapeutic Payloads (CATP) s

pmid

40851032

doi

10.1038/s42003-025-08735-z

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