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ESO-T01 · 9 patients in vivo BCMA CAR-T · r/r multiple myeloma · CRS in 4/5

在 5/16 抗体大会 Panel 3 上,panelist 讨论了 ESO-T01(EsoBiotec)的初步临床数据: - 总共描述 9 名 r/r multiple myeloma 患者 - 全部 9 名患者均成功在体内生成 CAR-T 细胞 - CAR-T 水平与 ex vivo delivery 相当 - 报告 vector infusion 后的 toxicity(不同于 ex vivo CAR-T) - CRS 出现在 CAR-T 注入后几天 - per Nature Medicine 2026 phase 1 报告:CRS in 4/5…

Type
evidence
Domain
oncology
Grade
conference
License
LIGHT_HOPE_proprietary
Provenance
m622_intel_seed_2026-05-16
evidence_grade
A
category
in_vivo_car_t_clinical_data
status
verified
instance_tag
sunvax-antibody-2025
clinical_claim_softening
"early IIT clinical data · feasibility demonstration · NOT validated late-stage clinical model · not intended to guide individual patient treatment choices"
indication
relapsed/refractory multiple myeloma (r/r MM)
patient_count
9
trial_id
TBD · IIT trial in China per EsoBiotec PR 2024-12-11
efficacy_summary
9/9 patients generated CAR-T cells in vivo · CAR-T levels similar to ex vivo delivery · extramedullary lesions eliminated · early efficacy signal · NOT validated late-stage outcome
safety_summary
CRS in 4/5 patients (3 grade 3) per Nature Medicine 2026 phase 1 report · 1 grade 1 ICANS · vector-infusion-related toxicity reported (different from ex vivo CAR-T) · NOT directly comparable to ex viv
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