Speed-of-Processing Cognitive Training in the ACTIVE Trial Shows a ~29% Relative Reduction in Dementia Risk at 10-Year Follow-Up

A US NIH-funded clinical trial reported that a specific speed-of-processing cognitive training was associated with a ~29% relative reduction in dementia risk at 10-year follow-up; the effect is modality-specific, and translation to general practice depends on adherence and protoc

Type

evidence-claim

Domain

h10_altered_intercellular_communication

Grade

B+

License

CC BY-NC 4.0

card_id

L-019

hallmarks

h10_altered_intercellular_communication

cluster

clinical_translation

primary_disease_area

alzheimers,longevity_general

evidence_tier

B+

evidence_anchor_count

4

intake_round

R23

intake_date

2026-05-26

related_experts

related_biomarkers

related_interventions

active_speed_of_processing_training

related_trials

collection_pages

/research/interventions/cognitive-training,/research/clinical-translation/non-pharmacological

LongProof Longevity Dynamic · LIGHT HOPE / x1000.ai · longevity.x1000.ai · 2026 · source

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