KCC2 Hypofunction Unifies Network Disinhibition Across Epilepsy, Neuropathic Pain, Spinal Cord Injury, and Alzheimer's-Associated Hyperexcitability

Multiple peer-reviewed studies suggest that disrupted neuronal chloride homeostasis (KCC2 hypofunction) contributes to network hyperexcitability across several CNS disorders. KCC2 potentiation is being investigated as a candidate cross-indication therapeutic mechanism, with one o

Type

evidence-claim

Domain

h10_altered_intercellular_communication

Grade

B

License

CC BY-NC 4.0

card_id

L-004

hallmarks

h10_altered_intercellular_communication

cluster

science_layer

primary_disease_area

epilepsy_refractory,neuropathic_pain,spinal_cord_injury,alzheimers

evidence_tier

B

evidence_anchor_count

6

intake_round

R23

intake_date

2026-05-26

related_experts

TBD-Hegarty

related_biomarkers

related_interventions

int_axn_027,int_ov350,int_ov4071

related_trials

trial_actrn12624001294549

collection_pages

/research/mechanisms,/research/cross-disease-targets

LongProof Longevity Dynamic · LIGHT HOPE / x1000.ai · longevity.x1000.ai · 2026 · source

Read-only aggregated view. Longevity Evidence is the source of record; this catalog shows provenance as-is — no ratings, no reviews.