SymphonyAge: An 11-System DNA Methylation Age Captures System-Specific Aging Trajectories

Recent multi-cohort research suggests biological age may differ across organ systems within the same individual, with system-specific methylation patterns showing differential association with system-relevant disease outcomes.

Type

evidence-claim

Domain

h03_epigenetic_alterations

Grade

B+

License

CC BY-NC 4.0

card_id

L-003

hallmarks

h03_epigenetic_alterations,h10_altered_intercellular_communication

cluster

science_layer

primary_disease_area

longevity_general

evidence_tier

B+

evidence_anchor_count

3

intake_round

R23

intake_date

2026-05-26

related_experts

TBD-Sehgal

related_biomarkers

bm_symphonyage_11sys

related_interventions

related_trials

collection_pages

/research/biomarkers,/research/biological-age

LongProof Longevity Dynamic · LIGHT HOPE / x1000.ai · longevity.x1000.ai · 2026 · source

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